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Article
February 1943

MORPHOLOGY OF ERYTHROCYTES IN ERYTHROBLASTOSIS FOETALIS

Author Affiliations

MEDICAL CORPS, ARMY OF THE UNITED STATES

From the New York Hospital and the Department of Pediatrics, Cornell University Medical College.

Arch Intern Med (Chic). 1943;71(2):230-255. doi:10.1001/archinte.1943.00210020096007
Abstract

Acute hemolytic anemias due to autoantibody reactions have been observed in human beings1 and induced experimentally in animals.2 Hematologic examination of the experimental animals has revealed a fairly consistent pattern of morphologic change. During the initial phase of hemolysis, the mean cell diameter decreases and the mean cell volume increases, the cells assuming a spheroid shape. After several days the mean diameter rises above normal with the simultaneous appearance of macrocytes, nucleated red cells and increased numbers of reticulocytes. At this time the Price-Jones curve is frequently bimodal, and Dameshek has stressed this point as being of diagnostic import in such anemias. The recent work of Levine and his associates3 has shown that about 90 per cent of infants with erythroblastosis foetalis have an antigen, designated as Rh, in their blood cells which is inherited from the father, probably as a mendelian dominant character, and which the

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