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Article
September 1943

SULFADIAZINE ADMINISTERED ALONE AND WITH ANTIPNEUMOCOCCUS SERUM IN THE TREATMENT OF PNEUMOCOCCIC PNEUMONIA

Author Affiliations

Clinical Professor of Medicine, New York University College of Medicine, and Visiting Physician, Harlem Hospital and Willard Parker Hospital NEW YORK

From the Medical Service, Harlem Hospital, Department of Hospitals, New York city and the Littauer Pneumonia Research Fund of New York University College of Medicine These studies received additional support from the Metropolitan Life Insurance Company an from Mr. Bernard M. Baruch, Mr. Bernard M. Baruch Jr., Miss Belle N. Baruch and Mrs H. Robert Samstag.

Arch Intern Med (Chic). 1943;72(3):329-345. doi:10.1001/archinte.1943.00210090030003
Abstract

Sulfadiazine (2-[paraaminobenzenesulfonamido]-pyrimidine), the pyrimidine analog of sulfapyridine, has been shown by Feinstone and his associates1 in their experiments with mice to be less toxic than either sulfapyridine or sulfathiazole. They found the drug to be readily absorbed into the blood and rapidly excreted in the urine. Higher concentrations were obtained with sulfadiazine than with equivalent doses of sulfapyridine or sulfathiazole. Long and his co-workers2 reported that sulfadiazine was less effective at equivalent concentrations than sulfathiazole in the treatment of experimental pneumococcic infections in mice. Osgood and Bullowa,3 using tissue cultures, found sulfadiazine to be only one-quarter as effective against pneumococci as sulfapyridine and sulfathiazole in equivalent concentrations.

Studies on the action of sulfadiazine in human beings have been reported by various investigators.4 With an associate we5 have previously reported on the pharmacodynamics of the drug in man. It is well absorbed from the gastrointestinal tract.

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