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This monograph is a concise presentation of classic typhus. After a brief sketch of the history and the geographic distribution, in which are presented data on the recent epidemic in Spain, the disease is described in considerable detail. The etiology, clincal characterstics, pathologic anatomy, immunology, epidemiology and prophylaxis are all well outlined. Laboratory procedures useful in the study of the disease are also included. In an appendix several related rickettsial diseases, namely endemic typhus, tabardillo, Rocky Mountain spotted fever and others, are briefly mentioned for the sake of completeness.
The authors note that vaccination with the vaccine prepared by the method of Cox (United States Public Health Service) was tried in Spain. Their impression is that the vaccine did not protect against infection but that it served definitely to ameliorate an attack of the disease.
In a later publication (La prueba intradérmica de Giroud en la infección tifoexantemática, Rev. San.
Tifus exantemático: Etiología—clínica—profilaxis.. Arch Intern Med (Chic). 1943;72(4):564. doi:10.1001/archinte.1943.00210100137014