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March 1944

Pathology and Therapy of Rheumatic Fever.

Arch Intern Med (Chic). 1944;73(3):267. doi:10.1001/archinte.1944.00210150070010

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For many years rheumatic fever has been the subject of profound and tireless investigation by eminent clinicians, bacteriologists, pathologists, public health workers and other investigators. While much progress has been achieved toward a better understanding of the disease, it is generally conceded that the causation of rheumatic fever is still unsettled but that several factors participate. It is therefore amazing to note the uncompromising views expressed by the author of this text. The opening sentence of the book clearly depicts this: "Rheumatic fever is a noninfectious disease." The author contends that rheumatic fever is caused, not by a specific micro-organism or virus, but by a sensitization to antigens, protein in nature, which in most cases are products of micro-organisms. All consequent arguments are based on this premise.

The conventional ideas of incidence and personal factors of rheumatic fever are considered. The pathologic changes of the disease as they occur

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