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Article
June 1944

CLINICOPATHOLOGIC STUDIES OF RENAL DAMAGE DUE TO SULFONAMIDE COMPOUNDSA REPORT OF FOURTEEN CASES

Author Affiliations

MILWAUKEE

From the Department of Medicine, Marquette University School of Medicine, and the Medical Clinics and Department of Pathology, Milwaukee County General Hospital.

Arch Intern Med (Chic). 1944;73(6):433-443. doi:10.1001/archinte.1944.00210180003001
Abstract

It has become widely recognized that the kidney may be damaged in the course of therapy with sulfonamide compounds. Such renal complications may be classified roughly as follows: 1. Mechanical complications produced by masses of crystals of the sulfonamide compounds in the kidneys, pelves and ureters. These lead to obstructive lesions. This group may be further subdivided into (a) the extranephric, in which the concretions causing obstruction are within the pelves of the kidney or in the ureters, and (b) the intranephric, in which the concretions are in the kidney substance itself. 2. Toxic intrarenal lesions without mechanical obstruction. These lesions occur within the kidney and are not associated with mechanical obstruction but may be attributed to the toxic effect of the sulfonamide compound on the parenchymal tissue. This class may be divided into three groups, which represent different phases of the same reaction and are not distinct divisions: (a)

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