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December 1944


Author Affiliations


From the Department of Pharmacology and Therapeutics, Stanford University School of Medicine.

Arch Intern Med (Chic). 1944;74(6):424-427. doi:10.1001/archinte.1944.00210240014003

Ever since the experimental demonstration by Abelous and Bardier1 in 1909 that urine contains a "hypotensive" substance, periodically there have appeared favorable clinical reports of therapeutic usefulness of this or that tissue extract in treatment of hypertensive and myospastic states. The clinical usage has been practically limited to insulin-free pancreatic extracts which are also free from histamine and choline, the products most commonly used being depropanex and padutin. These and other similar extracts are not accepted by the Council on Pharmacy and Chemistry of the American Medical Association because of lack of convincing evidence of therapeutic value despite their experimental effectiveness on the circulation.2 The value of depropanex and padutin in treatment of intermittent claudication3 and of ureteral colic4 was formerly, and has been again recently, stressed. The scope of claims for their antispasmodic ac- tion has been extended to the relief of pain in angina

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