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In this book the authors give a review of their own experimental investigation and clinical experience, a digest of most of the modern works of other investigators and a comprehensive picture of the whole problem of arterial hypertension. Through their own experiences, they are well prepared to write a book such as this. The main part of the book deals with the genesis of renal arterial hypertension in man and in animals. The writers conclude that hypertension in man is not identical with the hypertension found in the experimental animal, and they emphasize the anatomic differences between the two forms.
Considerable space is devoted to the results of their pioneer investigations on renin, hypertensinogen and hypertensin. In brief, they hold to the theory that renin plus hypertensinogen produces hypertensin (angiotonin), which is responsible for the arteriolar constricting that produces hypertension. They discuss the enzyme hypertensinase, a substance from the kidney,
Hipertensión arterial nefrógena.. Arch Intern Med (Chic). 1945;76(1):62. doi:10.1001/archinte.1945.00210310070012