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October 1945


Author Affiliations


From the Division of Medicine (Dr. Olsen), the Section on Dermatology and Syphilology (Dr. O'Leary) and the Section on Roentgenology (Dr. Kirklin) of the Mayo Clinic.

Arch Intern Med (Chic). 1945;76(4):189-200. doi:10.1001/archinte.1945.00210340003001

The dermatoscleroses constitute a group of diseases in which changes of the connective tissues of the body are predominant. One of us (O'Leary1) has discussed four dermatologic entities: namely, scleroderma, acrosclerosis, scleredema and dermatomyositis, all of which have a certain degree of cutaneous sclerosis as part of the clinical picture. Fundamental disturbances of the connective tissues are involved in each of these syndromes. Scleroderma and acrosclerosis are alike in that sclerosing processes take place in the lower portion of the cutis. Acrosclerosis differs from scleroderma in that the trophic disorder in the former appears to have its origin in vasomotor disturbances. Acrosclerosis is a sclerodermic process which involves the distal parts of the extremities and the face and neck of patients who present the phenomena of Raynaud's disease. We believe that it constitutes a distinct clinical entity.

As Weiss and his associates2 have pointed out, the changes of

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