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Article
November 1946

PATHOGENESIS OF CIRRHOSIS OF THE LIVER OCCURRING IN PATIENTS WITH DIFFUSE TOXIC GOITER

Author Affiliations

NEW YORK

From the laboratories, Department of Pathology, the Mount Sinai Hospital.

Arch Intern Med (Chic). 1946;78(5):497-530. doi:10.1001/archinte.1946.00220050002001
Abstract

FROM THE standpoint of morphology, the liver has received abundant attention in fatal cases of diffuse toxic goiter. The lesions found are various; there are fatty changes, parenchymatous degeneration, venous congestion and, finally, cirrhosis of such a distinctive character as to be pathognomonic of this disorder. These lesions occur singly or in various combinations. In an appreciable percentage of cases no lesion of the liver is found. Acute yellow atrophy has been reported by Raab and Terplan,1 Kerr and Rusk,2 Zeldenrust and van Beek3 and Beaver and Pemberton.4 Foci of necrosis have been reported by Beaver and Pemberton,4 Habán,5 Rössle6 and Cameron and Karuntaratne.7 Whether focal necrosis represents an early or an abortive phase of acute yellow atrophy is questionable. Beaver and Pemberton found focal necrosis in 6.5 per cent of the livers of 107 patients afflicted with diffuse toxic goiter; in 5 patients the necrosis was of sufficient intensity to be

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