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Article
January 1947

TESTS OF LIVER FUNCTION IN SCHISTOSOMIASIS JAPONICAWith Particular Reference to Antimony Treatment and With Report of Two Autopsies

Author Affiliations

MEDICAL CORPS, ARMY OF THE UNITED STATES; SANITARY CORPS, ARMY OF THE UNITED STATES

Arch Intern Med (Chic). 1947;79(1):62-76. doi:10.1001/archinte.1947.00220070058001
Abstract

IT IS WELL known that repeated infection with schistosomiasis japonica may result in cirrhosis of the liver.1 American soldiers who contracted this disease on the island of Leyte in the Philippines during the fall and winter of 1944 had but limited exposure to the cercariae of Schistosoma japonicum, so that their ultimate prognosis may be quite different.2 During a serial study of tests of hepatic function in a group of 481 such patients, 2 died as a result of external violence about seven months after the onset of the disease, and their hepatic lesions were studied at autopsy, both grossly and microscopically. The observations on the hepatic lesions together with the results of tests of hepatic function done in relation to treatment in the whole group form the basis of this report.

REPORT OF CASES 

Case 1.—Clinical.  —This 23 year old patient was exposed to the

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