[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 54.161.216.242. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Article
February 1947

CARDIAC MANIFESTATIONS OF TOXIC ACTION OF EMETINE HYDROCHLORIDE IN AMEBIC DYSENTERY

Arch Intern Med (Chic). 1947;79(2):228-238. doi:10.1001/archinte.1947.00220080116006
Abstract

THE TOXIC action of emetine hydrochloride on the cardiovascular and neuromuscular systems has been well known for many years. In 1916 Levy and Rowntree1 demonstrated by means of the electrocardiograph that an overdose of emetine hydrochloride in rabbits caused death by ventricular fibrillation. More recently Boyd and Scherf2 observed intraventricular block, inversion of T waves and cardiac arrhythmias in experimental intoxication with emetine hydrochloride in cats.

In human beings the toxic effects of emetine hydrochloride on the neuromuscular system have been described more frequently than the cardiac manifestations. These consist principally in generalized muscular weakness, tremors and peripheral neuritis. Diarrhea, which may be bloody in severe conditions, vomiting and abdominal cramping pains are among the other commoner evidences of toxicity of emetine hydrochloride.

Although it has been well established that the long-continued administration of emetine hydrochloride in large doses in human beings will generally result in the development

First Page Preview View Large
First page PDF preview
First page PDF preview
×