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Article
July 1947

EFFECT OF AMINO ACIDS ON THE FUNCTION OF THE MUSCLES OF PATIENTS WITH MYASTHENIA GRAVIS

Author Affiliations

NEW YORK

From the New York Hospital and the Department of Medicine (Neurology) and Psychiatry, Cornell University Medical College.

Arch Intern Med (Chic). 1947;80(1):68-73. doi:10.1001/archinte.1947.00220130076006
Abstract

ACCORDING to a recently presented concept,1 much of the symptomatology in patients with myasthenia gravis can be explained by a decreased acetylcholine synthesis. Amino acids2 and proteins3 were found to increase the acetylcholine synthesis in vitro. It seemed reasonable, therefore, to investigate the effect of the infusion of amino acids on patients with myasthenia gravis.

METHOD  Records of muscle action potential were taken from healthy subjects and from patients with myasthenia gravis by the following method: The forearm was firmly fixed in the supine position onto a padded board by means of broad strips placed across the arm near the elbow and the wrist. Of the two silver recording electrodes (0.5 sq. cm.), one was fixed with adhesive tape to the skin over the ventral surface of the first phalanx of the fifth finger and the other over the surface of the hypothenar eminence at a distance

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