September 1947


Author Affiliations


From the Department of Pathology, Stanford University School of Medicine.

Arch Intern Med (Chic). 1947;80(3):397-402. doi:10.1001/archinte.1947.00220150107009

ALTHOUGH an increasing number of papers have appeared in recent years on the subject of atrophy of the testes and gynecomastia in cirrhosis of the liver, little of the work has been controlled by morphologic studies. Since atrophy and hyperplasia of tissues are to a large extent morphologic concepts, they cannot be completely evaluated without such studies. Glass, Edmondson and Soll,1 for example, stated that of 14 males hospitalized for chronic disease of the liver there was gynecomastia in 8 and testicular atrophy in all, presumably on the basis of clinical examination. This can be deceptive, however, as the following instance will illustrate. In a recent case of active Laennec cirrhosis coming to autopsy here the combined weight of the testes was 21 Gm.; the usual weight for a man of the age of the patient is 30 to 40 Gm. It might have been supposed that well developed

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