November 1947

On the Morphology of Blood and Bone-Marrow in Thyrotoxicosis.

Author Affiliations

Inaugural Dissertation. By O. Biström. Pp. 188. Acta chirurgica Scandinavica, volume LXCIV, supplementum 114. Stockholm: Norstedt & Söner, 1946.

Arch Intern Med (Chic). 1947;80(5):694. doi:10.1001/archinte.1947.00220170130014

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.


This monograph is a report of the condition of the blood and of the bone marrow obtained by aspiration in 24 control subjects, 26 patients with nontoxic goiter and 33 patients with thyrotoxicosis. The older literature is completely reviewed; practically no investigations have been reported on the bone marrow in thyrotoxicosis.

The patients with nontoxic goiter showed no important abnormalities. The more important deviations in the patients with thyrotoxicosis consisted of a lymphocytosis of the peripheral blood and a shift toward immaturity of the neutrophilic granulocytes and, to a lesser extent, of the normoblasts in the bone marrow. This shift was more distinct in the severely toxic forms of the disease. The described changes reverted toward normal after therapy with iodine or methylthiouracil and after thyroidectomy. The author does not feel that the inconstant and slight changes in the blood and bone marrow are of great importance in the prognosis

First Page Preview View Large
First page PDF preview
First page PDF preview