DESPITE extensive use of mercurial diuretics by intravenous administration for many years and although fatalities following such injections have been reported, the literature contains only a few articles concerning the immediate effect of mercury on the human heart as determined by electrocardiographic tracings. In order to study this effect, the present investigation was carried out.
A total of three hundred and nineteen intravenous injections of mercurial diuretic preparations were administered in 137 patients. The majority of patients were hospitalized during the period of study, the remainder being ambulatory. The main diagnosis was chronic congestive heart failure in 121 cases, cirrhosis of the liver in 7, the nephrotic stage of chronic glomerular nephritis in 6 and thyrotoxicosis in 3. The patients were unselected, the only requirement for inclusion in this series being the need for diuresis.Three different mercurial preparations were investigated. Mercurophylline injection was administered one hundred and
WOLFF L, SAGALL ES. INTRAVENOUS ADMINISTRATION OF MERCURIAL DIURETICS IN MANImmediate Effect on the Electrocardiogram. Arch Intern Med (Chic). 1948;81(2):137–144. doi:10.1001/archinte.1948.00220200025004