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Article
August 1948

ASSOCIATION OF HEPATIC INSUFFICIENCY WITH CHRONIC ULCERATIVE COLITIS

Author Affiliations

ANN ARBOR, MICH.

From the Department of Internal Medicine, University Hospital, University of Michigan Medical School, Ann Arbor, Michigan.

Arch Intern Med (Chic). 1948;82(2):159-174. doi:10.1001/archinte.1948.00220260049004
Abstract

THE OCCURRENCE of disease of the liver in association with chronic idiopathic ulcerative colitis has received little emphasis. Pylephlebitic abscess is occasionally listed as an uncommon, but fatal, complication of ulcerative colitis1 but nonsuppurative parenchymal hepatic disease is rarely mentioned. However, as early as 1899 Lister2 reported a case of diffuse ulcerative colitis associated with a secondary acute interstitial hepatitis characterized by a diffuse cellular infiltration in the liver and the presence of an abundance of "fat globules." It is of interest to note that even before the separation of "simple ulcerative colitis" from the dysenteries by Wilks and Moxon,3 Thomas4 reported a fatal case of ulceration of the colon in which the rapidly fatal termination was felt to be due to a pathologic process in the liver. The liver was described as being enlarged to twice normal size, much softened and in an advanced stage

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