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Article
December 1948

PROTHROMBINOPENIC EFFECT OF PENICILLIN

Author Affiliations

Affuleh, Israel.

Arch Intern Med (Chic). 1948;82(6):625. doi:10.1001/archinte.1948.00220290109009

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Abstract

To the Editor:  —Because of the war in our country we lost contact for a time with the recent American medical publications, and it has been only lately that we received the back numbers of the Archives of Internal Medicine.In the review on syphilis by F. W. Reynolds and J. E. Moore (Arch. Int. Med. 81:85 (Jan.) 1948) the action of penicillin on prothrombin in blood is mentioned. The authors quote reports from literature showing thrombopenic, as well as thromboplastic, effects of penicillin, without concluding which of these results is the correct one; but they add that there is no report of thrombotic accidents in medical practice after use of penicillin.In this connection I should like to direct your attention to the article "Prothrombinopenic Effect of Penicillin in Men" (Lewitus, Z. A., and Aschireli, A.: Harefuah 35:15 [July 15) 1948) in which

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