LYMPHOSARCOMA of the gastrointestinal tract is of interest not only because of its rarity but because of the diagnostic difficulties and its difference in therapeutic response from other malignant lesions of the gastrointestinal tract.
We have confined our observations to those cases in which the lesion was primary in one or several portions of the gastrointestinal tract. The cases in which there was widespread involvement of the lymph nodes, even though the gastrointestinal tract was also involved, were excluded because it may be assumed that this was the disseminated type of lymphosarcoma with multicentric primary foci. It is likely, however, that in some of these cases the condition may have begun as primary gastrointestinal lesions, with subsequent metastasis to lymph nodes and other organs. If only the regional lymph nodes were involved, the condition was considered as a primary gastrointestinal neoplasm with spread to regional lymph nodes.
SPELLBERG MA, ZIVIN S. LYMPHOSARCOMA OF THE GASTROINTESTINAL TRACTWith a Report of Twenty-One Cases. Arch Intern Med (Chic). 1949;83(2):135–149. doi:10.1001/archinte.1949.00220310018002