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Article
April 1949

RECRYSTALLIZED INSULIN FOR DIABETIC PATIENTS WITH INSULIN ALLERGY

Author Affiliations

STOCKHOLM, SWEDEN

From the Chemistry Department of the Caroline Institute.

Arch Intern Med (Chic). 1949;83(4):363-371. doi:10.1001/archinte.1949.00220330003001
Abstract

ALLERGIC reactions from insulin can be viewed from different aspects. They causedifficulties in insulin therapy, sometimes even making a discontinuation of treatment with insulin compulsory. Of no less interest from a theoretic point of view is the question of the presence or absence of antigenic properties in insulin. As a hormone common to all vertebrate animals, insulin could be assumed to have a definite molecular structure irrespective of the species from which it derives and should not be antigenic. Nevertheless, authors who review the literature on this topic (Yasuna1 and Watson2) tacitly accept the concept that insulin is an antigen, capable of inducing sensitization. Desensitization has consequently been considered as the last resort in cases of severe allergic reactions. Rapid (Corcoran,3 Ulrich and others4 and Bayer5) as well as prolonged (Weitz6) procedures for desensitization of the patients have consequently been worked out. If successful, the rapid desensitization eliminates the difficulties

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