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Article
September 1949

AEROSOL AND MICRONIZED EPHEDRINE AND PENICILLIN THERAPY OF DISEASES OF THE LOWER RESPIRATORY TRACTTreatment of Bronchitis, Bronchiectasis and Intrinsic Asthma

Author Affiliations

LOS ANGELES

From the Department of Medicine, University of California School of Medicine, Los Angeles, (Dr. Weinberg), and the Department of Medicine, General Medical and Surgical Hospital, Veterans Administration Facility (Dr. Packer).

Arch Intern Med (Chic). 1949;84(3):389-395. doi:10.1001/archinte.1949.00230030031003
Abstract

THE SEQUENCE of bronchial infection, bronchiectasis and fibrosis and asthma, with its enormous actual subsequent morbidity, has rightly led to considerable study of the well recognized favorable effects of penicillin inhalation therapy.1 The problem has been one of determining the easiest and least harmful method of placing the penicillin in contact with the offending bacteria. Inhalation has circumvented the prime defect of parenteral therapy, namely, deficient circulation of blood in the fibrosed areas, yet there has remained the barrier of the diseased and irritated bronchi and bronchioles. One of us (S. J. W.) had been impressed by observation of the long-continued relief afforded ambulatory persons with diverse types of chronic bronchial asthma by repeated inhalations of mechanically nebulized 3 per cent solution of ephedrine sulfate U. S. P. Similar use of vaporized epinephrine U. S. P. and other bronchodilators was reported several years ago.2 In the present experimental

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