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Article
November 1949

CLINICAL MANIFESTATIONS OF CARRION'S DISEASE

Author Affiliations

CHICAGO

From the Frank Billings Medical Clinic, Department of Medicine, University of Chicago.

Arch Intern Med (Chic). 1949;84(5):751-781. doi:10.1001/archinte.1949.00230050087005
Abstract

CARRIÓN'S disease is caused by Bartonella bacilliformis, a polymorphous organism classified as a bacterium in 1927 by Noguchi,1 transmitted by sandflies of the genus Phlebotomus. The disease is limited geographically to certain areas of the Andean regions in Peru, Colombia and Ecuador.

The disease is extremely polymorphic in symptoms. The confusion existing in the literature arose in part from reports prior to the discovery of B. bacilliformis, when intercurrent infections were not recognized and many symptoms were erroneously assigned to Carrión's disease. The present report is based on a study made on several hundred cases in Lima, Peru, during the period 1938 to 1943.

HISTORY AND NOMENCLATURE  Archeologic findings indicate that the disease was known in Peru in the pre-Incaic era. Surprisingly accurate representations of the cutaneous nodules, or verrugas, are found in the Peruvian ceramic pots called huacos, especially in the Chimu civilization.2 The first medical publication

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