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This monograph proposes the thesis that inadequacy of niacinamide ("aniacinamidosis") is the commonest cause of articular dysfunction. This disorder is reputedly "exceedingly prevalent in many individuals [with or] without joint complaints or clinically obvious arthritis" (page 3). Also "exceedingly prevalent in the group of patients studied" were psychosomatic symptoms and signs (page 130).
Data are based on a study of 455 patients aged 4 to 78 years, seen over a two year period from 1945 to 1947 inclusive. A weighted average of twenty joint measurements constituting a "joint range index" is used to classify severity, dosage requirement and response to treatment. The reported dosage of niacinamide ranged from 400 mg. to 4,000 mg. daily in divided oral doses. Additional components of the B complex, vitamin C and other medical and psychotherapeutic measures were also prescribed. "No matter what associated diseases the patient had, his joint dysfunction responded in a predictable
The Common Form of Joint Dysfunction: Its Incidence and Treatment.. Arch Intern Med (Chic). 1950;85(2):364. doi:10.1001/archinte.1950.00230080168024