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Article
February 1951

OBSERVATIONS ON A CASE OF IDIOPATHIC HYPOPARATHYROIDISM

Author Affiliations

SHEFFIELD, ENGLAND

From the Department of Biochemistry and the University Department of Medicine, The Royal Hospital, United Sheffield Hospitals.

AMA Arch Intern Med. 1951;87(2):242-258. doi:10.1001/archinte.1951.03810020064006
Abstract

CHRONIC parathyroid insufficiency, in persons who have not had an operation on the thyroid gland, is an exceedingly rare condition. Drake, Albright, Bauer and Castleman,1 who reported six cases with autopsy observations in one of them, were able to collect from the previous literature only eight other instances which satisfied their diagnostic criteria. They considered that to justify the diagnosis there must be symptoms and signs of chronic tetany, a low serum calcium level, a raised serum inorganic phosphate level, evidence of normal renal function and absence of roentgenologic abnormalities in the bones. The last stipulation, however, requires modification, since increased density of bones has been reported in examples of the syndrome by Sevringhaus2 and by Taubenhaus and Engle,3 as well as by Emerson, Walsh and Howard,4 who stated that Albright, after seeing one of their patients, reexamined the roentgenograms of his own juvenile patients and

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