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The stated purpose of the authors is to condense the facts, crystallize the essence and present the practical application of our knowledge of the antihistamines. In the section on experimental studies they consider the role histamine plays in anaphylaxis and allergy; while the histamine theory is tenable only as a partial explanation, there can be little doubt that histamine is involved in these conditions. Histamine manifestations can be controlled by means of one or more of the following sequences: (1) preventing the antibody-antigen union; (2) modifying the action of liberated histamine by drugs which have a reversing action (epinephrine); (3) inactivating the histamine (histaminase); (4) desensitizing the tissues against the action of histamine by graded doses of histamine itself; (5) blocking the action of histamine by compounds which unite with or compete for histamine or which fix themselves on the effector cells and so inhibi the action of histamine; (6)
The Antihistamines.. AMA Arch Intern Med. 1951;87(2):328. doi:10.1001/archinte.1951.03810020150027