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Article
April 1951

RESOLUTION OF MILIARY TUBERCULOSIS OF THE BONE MARROW WITH DIHYDROSTREPTOMYCIN THERAPY

Author Affiliations

MINNEAPOLIS

From the Department of Internal Medicine, Minneapolis General Hospital.

AMA Arch Intern Med. 1951;87(4):594-597. doi:10.1001/archinte.1951.03810040119009
Abstract

RESOLUTION of the lesions of miliary tuberculosis before the advent of chemotherapy was a rare occurrence.1 Reports are available on the regressive and healing effects of streptomycin in miliary tuberculosis in experimental animals and on human material.2 The healing process is generally believed to be slow, requiring many weeks or months.

This is a report of a case of disseminated miliary tuberculosis of the reinfection type. The diagnosis was made on sternal bone marrow examination, utilizing the method described by Schleicher,3 in the absence of roentgenographic or clinical findings. It was possible to follow by histological means the rapid and almost complete resolution of the miliary tubercles in the bone marrow aspirations during dihydrostreptomycin therapy. A search of the literature has failed to reveal a previous report of this type.

REPORT OF CASE  M. D., a 52 year old white woman, was admitted to the Medical Service

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