THE REPORTED success of Lewin and Wassén1 in the treatment of rheumatoid arthritis with desoxycorticosterone acetate (DCA) and ascorbic acid indicates the importance of adequate studies to evaluate this therapy on an objective basis. Practically all the subsequent reports,2 which appeared in rapid succession after the original publication, were of a clinical nature with little objective evidence. In most of these reports the period of observation was much too short, considering the variability and chronicity of the disease.
The program of study in the present investigation included the following: (1) administration of a low sodium diet; (2) careful and frequent clinical evaluations; (3) substitution of placebos at varying intervals without the knowledge of the participating physicians; (4) daily record of body weight; (5) frequent blood pressure determinations; (6) roentgenograms of heart and lungs; (7) electrocardiograms; (8) complete blood counts; (9) total circulating eosinophil count before (control) and four
LITTMAN DS, STOCKDALE RH, WILLIAMSON GR. DESOXYCORTICOSTERONE ACETATE AND ASCORBIC ACID IN THE TREATMENT OF RHEUMATOID ARTHRITIS. AMA Arch Intern Med. 1951;87(5):707-712. doi:10.1001/archinte.1951.03810050085008