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Article
July 1951

CATION EXCHANGE RESIN IN TREATMENT OF THE NEPHROTIC SYNDROME

Author Affiliations

LOS ANGELES

From the Institute for Medical Research, Cedars of Lebanon Hospital.

AMA Arch Intern Med. 1951;88(1):9-16. doi:10.1001/archinte.1951.03810070019002
Abstract

THE USE of cation exchange resin for the relief of edema was first suggested by Dock1 in 1946. Since that time, several studies have been performed on animals2 and on man3 with results that were summarized by Dock4 in 1950. These experiences have indicated that treatment with the cation exchange resin is of real value in the control of cardiac edema and edema from other sources. However, difficulty has arisen from several sources during the administration of resin.

This paper deals with the observation of effects and toxicity of cation exchange resin in 14 patients with the nephrotic syndrome, treated during a period of one year. It is a compilation of several experiences which have demonstrated the striking benefits that may accrue to the nephrotic patient from resin administration and also the danger of the severe toxicity that may occur.

METHODS AND MATERIALS  The cases of

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