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Carefully controlled experiments were undertaken in the treatment of oral cancers to compare the effects of gamma rays from a radium beam and x-rays of 185 kv. constant potential. The principal difference noted was in the skin reaction. Skin erythema and mucous membrane reaction developed more rapidly and were severer in the patients treated with x-rays. Other experiments demonstrated the ratio of gamma ray dose to x-ray dose for the same severity of skin reaction was 1.34. A new statistical method was developed by the authors for estimating the proportion of patients cured by the use of the interim clinical results. By these methods, the estimated cure rate was 31 per cent for patients treated with radium beam and 19.2 per cent for those treated by x-ray beam. However, the difference of 11.8 per cent is less than 1.62 times its standard error and cannot be considered significant. Serial biopsies
Researches on the Radiotherapy of Oral Cancer.. AMA Arch Intern Med. 1951;88(1):133. doi:10.1001/archinte.1951.03810070143015