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Gray's synthesis of the seemingly divergent facts regarding the physiology of pulmonary ventilation is a strong case for the essentially cooperative nature of "independent" physiological regulatory systems. The development of the "multiple factor" theory, especially in response to the impetus given to pulmonary research in aviation medicine during World War II, has been interesting to observe and gratifying in its clarification of erstwhile paradoxes. Current physiological literature reflects the insight which may be gained into this clinically important field by the application of this approach. Admittedly not all phenomena of pulmonary regulation are known, and some now observed are not incorporated into the present integral devised by Dr. Gray, but it seems evident that a sound basic principle has been established on which further elaborations can be made. The book is clearly written and should be read by all research and clinical workers in this field. It may well point
Pulmonary Ventilation and Its Physiological Regulation.. AMA Arch Intern Med. 1951;88(3):415. doi:10.1001/archinte.1951.03810090146030