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The first chapter of this book deals with the history of heparin and its chemistry. It ends with a citation from Jorpes that so far it has been impossible to obtain pure heparin with welldefined chemical and physiologic properties. Attention is called to the relationship of the basophilic cells to the formation and storage of heparin. The action of heparin on coagulation is discussed. In association with a constituent of the plasma, heparin can inhibit the activation of prothrombin, but its main action seems to be that of an antithrombin. The formation of this antithrombin also requires the presence of an ingredient of the serum. The fibrinolytic activity of heparin is emphasized. A relatively simple colorimetric method for the determination of this activity is based on the faculty of the fibrin to adsorb carmine red, which is liberated on liquefaction of the fibrin. This fibrinolytic activity can be demonstrated in
Heparin und Heparinoide, Dicumarol: Möglichkeiten und Ergebnisse einer thrombostatischen und thrombolytischen Therapie.. AMA Arch Intern Med. 1951;88(4):550-551. doi:10.1001/archinte.1951.03810100134023