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The introduction to this work sketches the development of the concept of disease through stages, such as humoral, organ, cellular pathology, and others. For convenience, a classification based on organ pathology is adhered to, even though this contradicts the concept of totality and is regarded as unbiologic.
The first major subdivision is devoted to the co-ordination of circulation, respiration, blood, and metabolism. Considerable emphasis is laid on antagonism between the sympathetic and parasympathetic nervous systems. It is to be regretted that the book does not concern itself more with the pharmacology of sympathicomimetic and parasympathicomimetic drugs which have been used rather widely to test the state of the autonomic nervous system. Fever and myeloid leucocytosis are given as indications of a sympathicotonic effect. Pyrifer (a bacterial protein preparation) is said to give the same effect, but the fact is not mentioned that fever and myeloid tendency do not always go
Klinische Physiologie und Pathologie.. AMA Arch Intern Med. 1951;88(4):551-552. doi:10.1001/archinte.1951.03810100135024