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In this monograph, the authors have investigated and described the reaction of portions of exposed colons in four fistulous subjects. They observed the response of the colon directly by pharmacological and physical agents, and also the reaction of the colon when the patients were stimulated during anger and fear and during satisfaction and pain.
In their study they noted color changes in the mucosa of the colon, changes in secretory response and motor activity, and changes on kymographic tracings.
They are of the opinion that in all four fistulous subjects they were able to demonstrate that situations productive of conflict, resentment, and hostility were associated with hypermotility and hypersecretion of the enzyme lysozyme and of mucus. Dejection and fear, however, were associated with hypofunction of most of the large intestine. Pallor and relaxation were observed, as well as diminished contractile activity and low concentration of lysozyme in colonic secretions. In
The Human Colon: An Experimental Study Based on Direct Observation of Four Fistulous Subjects.. AMA Arch Intern Med. 1952;89(1):164. doi:10.1001/archinte.1952.00240010174015