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Article
April 1952

EFFECT OF THERAPY ON BLOOD VOLUME, BLOOD PRESSURE, AND SPLEEN SIZE IN POLYCYTHEMIA VERA

Author Affiliations

BERKELEY, CALIF.

From the Section on Experimental Medicine, Donner Laboratory of Medical Physics, University of California, Berkeley, Calif.

AMA Arch Intern Med. 1952;89(4):584-590. doi:10.1001/archinte.1952.00240040063008
Abstract

IT HAS LONG been known that marked increases in total blood volume occur in polycythemia vera and that the increase is due primarily to an increase in the total red cell volume.1 Relatively little, however, has been written concerning serial determinations of the blood volume, total red cell volume, and plasma volume during therapy of this disease. Brown and Giffin1a were the first to report on this phase; they studied five patients treated with phlebotomy and x-rays, doing two or three determinations on each patient. Later Haden2 studied one patient, and shortly thereafter Gibson and associates1b reported on a series of three patients studied in a similar manner. Of the nine patients followed by these three groups, eight showed an over-all fall in total red cell volume, associated with a fall in red blood cell count and hemoglobin concentration. The fall in total red cell volume was accompanied with a

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