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May 1952


Author Affiliations


From the Thorndike Memorial Laboratory, Second and Fourth Medical Services (Harvard), Mallory Institute of Pathology, Neurological Service, and First and Third Medical Services (Tufts), Boston City Hospital; the Departments of Medicine and Neurology, Harvard Medical School, and the Department of Medicine, State University of New York Medical Center at Syracuse, N. Y.

AMA Arch Intern Med. 1952;89(5):759-782. doi:10.1001/archinte.1952.00240050073006

HUMAN toxoplasmosis has been recognized with increasing frequency since the first description of the disease by Jankû1 in 1923 and the demonstration by Wolf, Cowen, and Paige2 of Toxoplasma as a cause of congenital encephalomyelitis with hydrocephalus, intracerebral calcifications, microcephaly, chorioretinitis, and microphthalmos. Most of the cases in the literature have been of infants,3 and there is an impressive body of evidence that the infection is acquired in utero from mothers who present no signs of infection.4 A few cases of toxoplasmosis occurring in adults have been described. These have differed from the infantile form in that a maculopapular rash and evidence of pneumonitis, acute encephalitis, and myocarditis were prominent in the clinical picture, whereas cerebral calcifications or chorioretinitis have been absent.5

The first case considered to be toxoplasmosis in an adult was reported in 1940 by Pinkerton and Weinman.6 The patient was a 22-year-old Peruvian who died after a

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