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May 1952


Author Affiliations


From the Department of Medicine, Emory University School of Medicine, and the Medical Service, Grady Memorial Hospital, Atlanta.

AMA Arch Intern Med. 1952;89(5):797-801. doi:10.1001/archinte.1952.00240050111008

THE CLINICAL course of meningitis due to Cryptococcus neoformans (Torula histolytica) is usually one of steady progression to death within a few weeks or months. Occasionally, however, the disease may exhibit great chronicity, lasting for years. One patient lived five and a half years1; Reilly and Artman reported on a patient who was still living, though not wholly well, nine years after the onset.2 Two instances of "recovery" have been reported,3 but in neither of these was the spinal fluid normal at the time of the last observation.

Herewith is reported the case of a young woman who died of cryptococcic meningitis after an illness lasting nearly 16 years.

REPORT OF CASE  At the onset of her symptoms the patient was 18 years of age. In the latter part of June. 1935, she began to complain of severe headache, diplopia, and blurring of the vision. On Aug.

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