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Article
September 1952

ROLE OF THE CENTRAL NERVOUS SYSTEM IN METABOLISM OF ELECTROLYTES AND WATER

Author Affiliations

CHAPEL HILL, N. C.; DALLAS, TEXAS; ALBANY, N. Y.; NEW HAVEN, CONN.

From the Departments of Internal Medicine and Surgery, Yale University School of Medicine, New Haven, Conn.

AMA Arch Intern Med. 1952;90(3):355-378. doi:10.1001/archinte.1952.00240090076007
Abstract

AN INTEREST in the influence of the central nervous system on the metabolism and excretion of electrolytes and water dates back at least to the middle of the 19th century, when Bernard1 observed a diuresis unrelated to glycosuria following puncture of a particular area of the floor of the fourth ventricle. His observation was confirmed and extended by Jungmann and Meyer.2 Since that time a considerable body of data has accumulated concerning the manner in which special structures within the central nervous system respond to and participate in the control of the volume and tonicity of the body fluids. The interrelationships among these several influences are quite intimate and so ordered as to provide a series of automatic adjustments that allow a high degree of precision in the control of the several dimensions of body fluid in health and in disease.

The ingestion of those materials that comprise

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