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November 1952


Author Affiliations


From the Departments of Internal Medicine and Pathology, Michael Reese Hospital, Chicago. The Department of Pathology is in part supported by the Michael Reese Research Foundation.

AMA Arch Intern Med. 1952;90(5):660-676. doi:10.1001/archinte.1952.00240110086009

SYSTEMIC involvement of lymphoid tissue is a well-recognized feature of rheumatoid arthritis.1 Among patients with rheumatoid arthritis, 50 to 75% may be found to have palpable lymph nodes.2 These nodes usually are painless, nontender, discrete, and movable under the skin. They may vary from small pea-sized structures to sizable lymph nodes (up to 3 cm.) which immediately attract clinical attention. They may be at the usual sites of clinically discernible lymph node enlargement, such as in the axillary, epitrochlear, cervical, and inguinal areas. Some patients, however, show enlarged lymph nodes at unusual sites, such as along the course of vascular channels of mid-arm or mid-thigh.3 It is now generally believed4 that the lymph node involvement represents participation of the lymphatic apparatus in the systemic disease, which rheumatoid arthritis is believed to be, rather than regional lymphadenopathy secondary to drainage from diseased joints. This belief is further strengthened by the finding

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