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Article
January 1953

BONE MARROW DEPRESSION FROM CHLORAMPHENICOL

Author Affiliations

NEW YORK

From the Department of Medicine, Memorial Center for Cancer and Allied Diseases, and the Division of Clinical Investigation, Sloan-Kettering Institute.

AMA Arch Intern Med. 1953;91(1):43-48. doi:10.1001/archinte.1953.00240130051005
Abstract

IN RECENT months several reports have appeared incriminating chloramphenicol as an etiological agent in bone marrow depression.1 Most of these reports have described patients with an established anemia and hypoplastic marrow who gave a history of having received varying amounts of chloramphenicol.2 A few have described patients in whom neutropenia developed during a course of the antibiotic.3 The present article reports serial observations on a patient who, while undergoing hematological study for other purposes, showed evidence of depression of erythropoiesis and of granulopoiesis during an episode of treatment with chloramphenicol.

REPORT OF CASE 

History.  —A 51-year-old white man, an electrician, was admitted on Feb. 11, 1952, to the James Ewing Hospital with a complaint of anemia of four years' duration.Four years before admission he consulted his local physician for a check-up, although he felt entirely well and had not sought medical consultation for the preceding 20

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