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Article
January 1953

FLACCID QUADRIPLEGIA, HYPERKALEMIA, AND ADDISON'S DISEASE

Author Affiliations

SAYLESVILLE, R. I.; NEW YORK

Dr. Marks was formerly Assistant Resident in Medicine, Montefiore Hospital for Chronic Diseases.; From the Medical Division, Dr. Louis Leiter, Chief, Montefiore Hospital for Chronic Diseases, New York.

AMA Arch Intern Med. 1953;91(1):56-67. doi:10.1001/archinte.1953.00240130064007
Abstract

THE RELATION of the adrenal glands to disturbances in electrolyte metabolism in man has been the subject of extensive investigation for nearly three decades. The importance of excessive renal sodium and chloride loss in the production of many manifestations of an Addisonian crisis has been well documented by a number of observers.1 The role of potassium in the pathogenesis of clinical signs and symptoms in patients with untreated Addison's disease has been less clearly demonstrated and at times controversial.2 We have recently had the opportunity to observe an unsuspected case of adrenal insufficiency in which the clinical picture was intimately related to the syndrome of potassium intoxication, a syndrome that has been reported frequently in primary renal insufficiency.3 Because of the rarity of this syndrome in Addison's disease and of the several atypical features observed in our patient, it was decided to report our case in considerable

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