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Article
August 1953

EFFECT OF NITROGEN MUSTARD ON CLINICAL COURSE OF GLOMERULONEPHRITIS

Author Affiliations

NEW YORK

From the Department of Medicine, New York University College of Medicine and the Third (New York University) Medical Division, Bellevue Hospital.

AMA Arch Intern Med. 1953;92(2):162-167. doi:10.1001/archinte.1953.00240200012002
Abstract

REMISSIONS in the nephrotic phase of glomerulonephritis occur spontaneously and may follow intercurrent infections. Blumberg and Cassady1 and Janeway and associates2 have reported that transient reduction in protein excretion and diuresis may follow acquired or induced measles in patients in the nephrotic phase of glomerulonephritis. Since remissions might be related either to factors present in the plasma of patients with acute infections or to disturbances in renal hemodynamics which accompany fever,3 we examined the effects of the infusion of plasma from patients acutely ill with bacterial infections as well as the effects of typhoid vaccine-induced pyrogenic reaction in patients with glomerulonephritis but failed to induce a remission.4 Becker5 has demonstrated that the administration of methyl-bis (β-chloroethyl) amine hydrochloride (nitrogen mustard) prevents the development of the Shwartzman phenomenon in rabbits. Schwab and associates6 have reported that experimental nephritis in rabbits produced by the administration of bovine serum gamma globulin can be

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