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Article
August 1953

TREATMENT OF RHEUMATOID ARTHRITIS WITH P-AMINOBENZOATE AND ACETYLSALICYLIC ACID

Author Affiliations

PHILADELPHIA; WILMINGTON, DEL.

From the Department of Medicine, Temple University School of Medicine (Drs. Zarafonetis, Steiger, and Ginsburg) and the Delaware Hospital (Dr. Heather).

AMA Arch Intern Med. 1953;92(2):204-215. doi:10.1001/archinte.1953.00240200054007
Abstract

MEASURES introduced for the treatment of rheumatoid arthritis have two points of major interest and value. First, any treatment which may mitigate the symptoms and contribute to the rehabilitation of persons suffering with this disorder possesses intrinsic merit. Second, the demonstration that an agent, or a combination of agents, can modify certain manifestations of rheumatoid arthritis may further contribute to the over-all knowledge of the pathologic physiology of this disease of unknown etiology. It appears warranted, therefore, to report at this time data which indicate that p-aminobenzoic acid and acetylsalicylic acid, in appropriate combination, are capable of producing beneficial effects in a significant proportion of patients with active rheumatoid arthritis.

The considerations which led to the use of this particular combination of therapeutic agents stem largely from a long-range study of the clinical effects of p-aminobenzoic acid. This substance is a member of the B-complex group of vitamins

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