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The frontispiece to this book is an effective ink sketch by the author illustrating an apt quotation from Shakespeare's "Macbeth." It shows three heavy weights tugging at the heart —thyroid, catecholamines, and mineralocorticoids. The author's professed aim is to crusade for the idea that neuroendocrine and endocrine influences play a fundamental role in the origin and treatment of cardiovascular disorders. That he means business is documented by 3,726 references. The book contains the mass of evidence in a heavy style, of unduly long sentences, unrelieved by the "skill and sparkle" promised in the publisher's blurb.
As to the contents, they suffice for several crusades for the basic idea. The first part deals with experimental cardiovascular effects of hormones and neurohormones. It is a thorough review of the complex interrelations between circulatory hormones, electrolytes, myocardial and vascular function, and cardiovascular morphology. The thesis is well supported that the sodium concentration in
Hormonal and Neurogenic Cardiovascular Disorders: Endocrine and Neuro-Endocrine Factors in Pathogenesis and Treatment.. AMA Arch Intern Med. 1953;92(5):765-766. doi:10.1001/archinte.1953.00240230165020