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Previous studies on the multiplication of PR 8 influenza virus have shown that under certain conditions an incomplete virus was formed. It was detected by the fact that it will react with specific antiserum, but it will not produce infection in chick embryos or mice.
In this investigation, Preben von Magnus makes a thorough study of some of the factors (such as concentration of inoculum, length of incubation period, and site of inoculation in chick embryos) on the production of the incomplete virus.
This is an excellent piece of work, but it is of greatest interest to the virologist and not to the practicing physician.
Propagation of the PR 8 Strain of Influenza A Virus in Chick Embryos: Studies on the Factors Involved in the Formation of Incomplete Virus upon Serial Passage of Undiluted Virus.. AMA Arch Intern Med. 1954;93(3):478. doi:10.1001/archinte.1954.00240270164023