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Article
May 1954

FURTHER EVALUATION OF HYDRALAZINE IN TREATMENT OF HYPERTENSIVE DISEASE

Author Affiliations

CLEVELAND

From the Research Division of the Cleveland Clinic Foundation and the Frank E. Bunts Educational Institute.

AMA Arch Intern Med. 1954;93(5):705-712. doi:10.1001/archinte.1954.00240290063007
Abstract

HYDRALAZINE has come into wide use in treatment of hypertensive disease during the past two years. Opinions as to its usefulness, practicality, and even as to its effectiveness are still widely varied. Thus, we1 found that one-half of a group of patients, many of them with severe disease, responded favorably to its administration over periods of 3 to 12 months; more recently, Hilker, Rhoads, and Billings2 reported a similar incidence of benefit and recommended the drug as a moderately effective antipressor agent useful in office practice. Johnson3 found it an effective hypotensive agent in 65% of his patients treated on an ambulatory basis. However, others* find it of limited value; some use it largely as an adjuvant in association with other antipressor drugs,† and some9 consider it quite ineffective.

In this report we shall describe observations in our previously studied patient group which will demonstrate the effect of 14 further

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