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May 1954


Author Affiliations


From the Medical Clinics of the Peter Bent Brigham Hospital; Life Insurance Medical Research Fellow, Assistant in Medicine (Dr. Robin) and Chief Resident in Medicine (Dr. Thomas).

AMA Arch Intern Med. 1954;93(5):713-724. doi:10.1001/archinte.1954.00240290071008

THE FREQUENT association of pulmonary edema and pneumonia in postmortem material is well known. This finding has usually been considered a mere coincidence and is often classified as a "terminal" finding. The use of the term "terminal" has in a sense been unfortunate, since it has served and sufficed as an explanation for the frequent simultaneous occurrence of these two pathological processes. Thus there has been a tendency to avoid an attempt to answer several important questions raised by the frequent concurrence of pulmonary edema and pneumonia in pathological material. These questions include the following:

  1. Is the frequent simultaneous occurrence merely a coincidence or is there a pathophysiological relationship between pulmonary edema and pulmonary inflammation?

  2. If such a relationship exists, does it only occur in the dying or does it also obtain in those who recover and, if so, under what conditions?

  3. Are there any therapeutic or prophylactic

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