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May 1955


AMA Arch Intern Med. 1955;95(5):739-760. doi:10.1001/archinte.1955.00250110109014

RECENT progress in purifying hormone preparations of the adenohypophysis has greatly facilitated the tracing of the metabolic effects of the anterior lobe to specific actions of the individual pituitary principles. Among these, the growth hormone (GH), or somatotrophic hormone (STH), has lately been studied intensively. The findings have thrown some light on the means by which this hormone controls protein, carbohydrate, and fat metabolism without the mediation of any target gland.

PROTEI N  Two major metabolic changes have long been considered prominent features of the effect of GH on protein or nitrogen metabolism: (1) a decrease in the urinary excretion of nitrogen and (2) a fall in the concentration of nonprotein, mainly amino acid, nitrogen in the blood and tissues.Decreased urinary excretion of nitrogen (especially in the form of urea) has been taken as evidence of an accumulation of nitrogenous material available for anabolic processes leading to cell growth

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