BY THE USE of filter-paper electrophoresis, the hematologist has gained a relatively simple and accurate method of differentiating the various abnormal or atypical hemoglobins.* Thus, we may identify normal hemoglobin (A), sickle hemoglobin (S), the combination of these (S-A) and C-hemoglobin in its homozygous (C-C) and heterozygous (C-A, C-S) states. From a practical standpoint, anemias which previously were undiagnosed or considered to be atypical sickle-cell anemia may be recognized now. It is the purpose of this paper to add to the literature another case of homozygous hemoglobin-C disease which was of particular interest because of the relatively long documented course of the illness, which prior to paper electrophoresis had been undiagnosed. The patient was followed intermittently from 1948 (when she first presented herself for treatment, with symptoms suggestive of gall-bladder disease) to 1953, when the syndrome was recognized and confirmed by paper electrophoresis.
METHOD OF ELECTROPHORESIS
A small tank was
ORVIS HH, HOLLY PB, SMITH NE. HEMOGLOBIN-C DISEASE. AMA Arch Intern Med. 1955;96(1):126-130. doi:10.1001/archinte.1955.04430010140011