October 1955

The Use of Myleran in the Treatment of Chronic Myelocytic Leukemia

Author Affiliations

Salt Lake City

From the Department of Medicine, University of Utah College of Medicine, American Cancer Society Clinical Fellow (Dr. Haut and Dr. Altman).

AMA Arch Intern Med. 1955;96(4):451-462. doi:10.1001/archinte.1955.00250150025002

A sulfonic acid ester, Myleran (1,4-bis [methylsulfonyloxy] (Fig. 1), synthesized by Timmis,1 was introduced by Galton 2 for the treatment of chronic myelocytic leukemia. This agent appears to be so promising that it seemed worth while to publish a full account of our own experience with it. Preliminary findings in some of our cases have been reported already.3 In addition to the latter and the 19 patients treated by Galton,2 the results of treatment of only 40 other cases have been reported until now.*

MATERIAL  Since November, 1952. we have used Myleran in the treatment of 16 consecutive cases of chronic myelocytic leukemia (Table 1). Eleven had received no previous therapy; five cases had been treated earlier with x-rays, nitrogen mustard, triethylenemelamine, or radioactive phosphorus. The interval from the apparent onset of leukemia to the start of Myleran therapy ranged from 1 month to 56 months; in seven cases it

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