January 1956


AMA Arch Intern Med. 1956;97(1):99-104. doi:10.1001/archinte.1956.00250190115011

DURING the past decade since the advent of streptomycin, changes in the treatment of tuberculosis in its various forms have occurred with almost bewildering rapidity. This period of transition has been marked by considerable difference of opinion as to the antimicrobial regimen of choice, duration of treatment, indications for surgical intervention, etc.* However, there is general agreement that specific antimicrobial therapy is indicated in all forms of active tuberculosis, regardless of the organs or system involved. The treatment of pulmonary tuberculosis will be considered first.


Drug Therapy  The drugs most commonly used today are isoniazid, streptomycin (or dihydrostreptomycin), and sodium aminosalicylate (PAS-sodium). Viomycin is used much less often. Pyrazinamide in combination with isoniazid is another drug combination which may emerge after further investigation as a significant addition to the armamentarium.10

Streptomycin Sulfate.  —This is one of the most effective antimicrobial agents we have for tuberculosis. It should not be used alone because of

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