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In a previous review (Journal of Industrial Hygiene and Toxicology19:349, 1937), the author covered the general field of the halogenated aliphatic hydrocarbons with respect to their toxicity and potential dangers. Since the publication of this review, many new halogenated hydrocarbons have been synthesized and a number of them have assumed importance in industrial, agricultural, and domestic usage.
The halogenated hydrocarbons are much more toxic than their parent hydrocarbons, and there appears to be no consistent relationship between toxicity and halogen content. Therefore, the toxicity must depend on the molecules themselves, and it becomes necessary to analyze each compound individually with respect to pharmacological activity, despite the many similarities in behavior of homologous series.
In the present work, the coverage of halogenated aliphatic hydrocarbons has been extended to include (1) halogenated aliphatic hydrocarbons (methane through hexane); (2) halogenated olefinic hydrocarbons (ethene through pentene); (3) halogenated diolefinic hydrocarbons, and (4)
Dragstedt CA. The Halogenated Hydrocarbons: Their Toxicity and Potential Dangers.. AMA Arch Intern Med. 1956;97(2):261–262. doi:10.1001/archinte.1956.00250200137014